| ncRNA name | hsa-miR-125a-5p |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples; human RB cell lines Y79 and WERI-RB1 |
| Methods | immunohistochemistry, Western blot, microarray, qRT-PCR, luciferase reporter assay, xenograft |
| Expression pattern | down-regulated |
| Functional description | miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma. Thus, the miR-125a-5p/TAZ/EGFR axis may be a potential therapeutic target for retinoblastoma. |
| PubMed ID | 27094723 |
| Year | 2016 |
| Title | Suppression of microRNA-125a-5p upregulates the TAZ-EGFR signaling pathway and promotes retinoblastoma proliferation. |
| Drug-related ncRNA | NO |
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